Flow in a fibril-forming disease.
نویسندگان
چکیده
منابع مشابه
Fibril-Forming Motifs Are Essential and Sufficient for the Fibrillization of Human Tau
BACKGROUND The misfolding of amyloidogenic proteins including human Tau protein, human prion protein, and human α-synuclein is involved in neurodegenerative diseases such as Alzheimer disease, prion disease, and Parkinson disease. Although a lot of research on such amyloidogenic proteins has been done, we do not know the determinants that drive these proteins to form fibrils and thereby induce ...
متن کاملFE-Based Analysis of Hot Forming Process Using the Flow Stress Prediction Model
In hot forming process, the workpiece undergoes plastic deformation at high temperature and the microstructure of the workpiece changes according to the plastic deformation. These changes affect the mechanical properties of workpiece. In order to optimize this process, both the plastic deformation of workpiece and its microstructural changes should be taken into consideration. Since material be...
متن کاملFE-Based Analysis of Hot Forming Process Using the Flow Stress Prediction Model
In hot forming process, the workpiece undergoes plastic deformation at high temperature and the microstructure of the workpiece changes according to the plastic deformation. These changes affect the mechanical properties of workpiece. In order to optimize this process, both the plastic deformation of workpiece and its microstructural changes should be taken into consideration. Since material be...
متن کاملThe structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold.
Numerous human disorders are associated with the formation of protein fibrils. The fibril-forming capacity of a protein has been found in recent studies to be determined by a short segment of residues that forms a dual beta-sheet, called a steric zipper, in the spine of the fibril. The question arises as to whether a fibril-forming segment, when inserted within the sequence of a globular protei...
متن کاملFOR THE RECORD Cooperative hydrogen bonding in amyloid formation
Amyloid diseases, including Alzheimer’s and prion diseases, are each associated with unbranched protein fibrils. Each fibril is made of a particular protein, yet they share common properties. One such property is nucleation-dependent fibril growth. Monomers of amyloid-forming proteins can remain in dissolved form for long periods, before rapidly assembly into fibrils. The lag before growth has ...
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عنوان ژورنال:
- Blood
دوره 129 1 شماره
صفحات -
تاریخ انتشار 2017